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Vitamin D · Geography · Evolution · Clinical Reality

The Full Vitamin D Story —
Geography, Evolution, and
Why Scotland Changes Everything

Vitamin D advice built for a global population average is not vitamin D advice built for Scotland. The physics of UVB at 56 degrees north, the evolutionary dietary adaptations that modern living has cancelled, the shower gel you used this morning, the GrassrootsHealth data that maps what people at different latitudes actually need — and the honest position on supplementation for people who spend most of their year north of the line where UVB produces vitamin D.

Stephen Duncan
BSc (Hons) · PG Dip · MSc · FDN-P · Edinburgh
July 2026

Edinburgh sits at approximately 56 degrees north latitude. Oslo is 59 degrees. Helsinki is 60. The physics of UVB radiation at these latitudes means that from approximately October to March — five months of the year — the sun's angle is too low for UVB to penetrate the atmosphere at the wavelengths required for vitamin D synthesis in human skin. Not reduced. Not diminished. For practical purposes of vitamin D production, the winter sun in Scotland is non-functional.

During the brief window when UVB is theoretically available — April to September — cloud cover, indoor working patterns, glass windows (which block UVB entirely), clothing, modern sunscreen use, and the specific time of day required (sun angle above 45 degrees, which in Scotland is only available for limited hours even in summer) combine to ensure that most Scots are accumulating substantially less vitamin D from sun exposure than the population guidance implies.

And then there is the shower gel.

What nobody mentions about skin synthesis

When UVB radiation strikes the skin, it converts 7-dehydrocholesterol — a cholesterol precursor — into pre-vitamin D3. This compound is then converted to cholecalciferol (D3) by body heat over the following hours. Critically, this conversion and subsequent absorption of D3 from the skin's surface layer takes time. The prevailing evidence suggests that washing the skin within 24–48 hours of UVB exposure significantly reduces the amount of vitamin D produced from that exposure.

The modern habit of showering with soap or gel daily — which strips the skin surface along with the pre-vitamin D3 sitting on it — undermines skin synthesis even on the days when UVB exposure has occurred. This is not a fringe concern. It is a direct consequence of modern hygiene practices applied to a biological process that evolved over hundreds of thousands of years without soap, glass windows, or office buildings.

GLASS
Windows block UVB entirely. Sitting beside a sunny window produces warmth and visible light. It produces no vitamin D. UVB does not penetrate standard glass. The Scots office worker who sits near a window all day in summer is not synthesising vitamin D from that light.
ANGLE
Sun angle below 45 degrees produces no usable UVB. At Edinburgh's latitude, this eliminates the morning and evening sun entirely, and restricts the effective synthesis window even in summer to roughly 11am–3pm on clear days. Most working Scots are not outside between 11am and 3pm in summer.
SPF
SPF 15 blocks approximately 93% of UVB. SPF 30 blocks 97%. The public health advice to apply sunscreen before sun exposure is correct for skin cancer risk. It is directly counterproductive for vitamin D synthesis. Both things are true simultaneously.
SKIN
Darker skin requires significantly longer UVB exposure to produce equivalent vitamin D. Melanin is a natural UV filter — protective against skin damage, but requiring more sun time for synthesis. At Scottish latitudes, people with darker skin tones face a compounded insufficiency risk that conventional guidance rarely addresses specifically.
SOAP
Daily showering with soap or gel removes pre-vitamin D3 from the skin surface before it can be absorbed. The conversion and absorption process takes up to 48 hours. Washing immediately after sun exposure substantially reduces net vitamin D production from that exposure. Timing matters in a way that nobody is discussing.
AGE
Skin synthesis capacity declines with age. Older adults produce approximately 25% of the vitamin D per unit of UVB exposure compared to younger adults, due to reduced 7-dehydrocholesterol concentration in ageing skin. The population with the highest vitamin D insufficiency risk (older adults) has the lowest synthesis capacity.

What GrassrootsHealth shows — the data that changes the conversation

GrassrootsHealth is a public health research organisation that has conducted one of the largest ongoing prospective studies of vitamin D status in a real-world population — the D*Action project. Tens of thousands of participants across multiple countries have submitted vitamin D blood tests alongside detailed data on sun exposure, supplement use, body weight, and health outcomes. The D*calculator they have developed is the most sophisticated publicly available tool for estimating what an individual at a given latitude needs to reach a target blood level.

GrassrootsHealth D*Action Research
What the population data shows about latitude and vitamin D requirements
The GrassrootsHealth data consistently shows that individuals living at high latitudes — particularly above 50 degrees north — require substantially higher supplementation than those at lower latitudes to achieve equivalent blood levels. The D*calculator accounts for: current 25-OH-D blood level, target level, latitude, season, body weight, skin tone, and current sun exposure — and produces an individualised supplementation estimate rather than a population average.

A person in Edinburgh targeting 100 nmol/L in November with minimal sun exposure and a measured baseline of 45 nmol/L may require 3,000–5,000 IU daily to reach that target. The same calculation for a person in Madrid would produce a substantially different number. Generic "take 400–800 IU" advice — based on population averages that include people at much lower latitudes — is systematically inadequate for populations living in Scotland, Scandinavia, or northern England.
Visit the GrassrootsHealth D*calculator →

The GrassrootsHealth data also addresses the question of optimal blood levels empirically — looking at health outcomes across their participant population rather than deriving thresholds from bone health alone. Their findings consistently suggest that health outcomes across immune function, cancer risk, cardiovascular health, and all-cause mortality continue to improve up to approximately 100–125 nmol/L, with no clear additional benefit beyond 150 nmol/L and potential concerns above that range.

The evolutionary context — the dietary compensation that modern living cancelled

The relationship between latitude and vitamin D is not a design flaw. It is a design feature that has been undermined by modern living.

Evolution, Latitude, and the Food-Sun Trade-Off

Populations living at high latitudes for thousands of generations did not die of vitamin D insufficiency in the numbers that modern insufficiency rates would predict. The reason is dietary adaptation. The traditional diets of high-latitude populations — Scottish, Scandinavian, Inuit, Northern Russian — were exceptionally rich in the dietary sources of vitamin D that partially compensate for limited UVB exposure.

Herring, mackerel, salmon, cod, and other fatty fish contain vitamin D3 in meaningful quantities. Cod liver oil — a traditional staple across northern European populations — is one of the most concentrated dietary sources of both vitamin D and vitamin A. Organ meats, particularly liver, contain D3 alongside a cofactor matrix that supports its conversion and utilisation. Full-fat dairy from pasture-raised animals — including butter and traditionally made cheese — contributed to vitamin D intake across seasons.

The Scottish traditional diet of herring, oatmeal, liver, full-fat dairy, and occasional game was not arriving at that composition by accident. It was the result of thousands of years of adaptation to an environment that provided limited sunshine for five months of the year. The diet solved the problem that the latitude created. Modern living — processed foods, seed oils, refined carbohydrates, reduced organ meat consumption, factory-farmed animals fed indoors — has cancelled that adaptation. The sun restriction remains. The dietary compensation has largely gone.

There is also an open question about whether populations that have lived at high latitudes for many generations have developed some degree of adaptation at the level of VDR sensitivity or conversion efficiency — becoming more efficient at using whatever vitamin D is available. The evidence here is limited but the question is legitimate. The individual variation in vitamin D status and response to supplementation observed clinically is consistent with this possibility, alongside the known genetic VDR polymorphisms that affect receptor sensitivity independently of latitude.

VDR genetics — why the same blood level means different things in different people

Vitamin D Receptor Polymorphisms
Why two people with identical 25-OH-D results can have very different functional vitamin D status
VDR gene polymorphisms are common. Several variants — including FokI, BsmI, ApaI, and TaqI — affect receptor sensitivity and the efficiency with which calcitriol (active vitamin D) produces biological effects in target tissues. These are not rare mutations. They are common population variants that create genuine differences in vitamin D utilisation between individuals.
Clinical consequence: A person with reduced VDR sensitivity may need a higher blood level to achieve the same biological effect as someone with normal sensitivity. This is one reason why "one size fits all" vitamin D targets are inherently inadequate. The number that represents functional sufficiency for one individual may represent functional insufficiency for another, even if the 25-OH-D result looks identical.
Autoimmune context — a clinical note: In certain autoimmune conditions associated with intracellular chronic infection, the ratio of 1,25-OH-D (active) to 25-OH-D (storage) can be elevated — indicating active conversion in the context of immune activation rather than genuine sufficiency. In this context, supplementing the storage form may not be appropriate. The clinical picture, not the number alone, determines the intervention. This is not the majority case, but it is real and relevant for practitioners working with complex autoimmune presentations.
Magnesium and VDR function: VDR signalling requires magnesium at multiple steps. People who are magnesium insufficient — which is the majority of people on a Western diet — have impaired VDR function regardless of their vitamin D blood level. Addressing magnesium first, or simultaneously, is not optional when vitamin D is the clinical concern.

The honest position on supplementation

After everything in this post, the clinical position I hold on vitamin D supplementation for people living in Scotland is straightforward — even if getting there required this much context to justify it.

The Clinical Position — No One Size, Several Principles
What the evidence supports for supplementation at Scottish latitudes

Test first. A 25-OH-D measurement before supplementing tells you where you are and gives you a baseline against which to assess response. It takes the guesswork out of dose selection and makes the intervention evidence-based rather than assumed.

Address cofactors simultaneously. Magnesium (bisglycinate or glycinate, 300–400mg daily) and vitamin K2 (MK-7, 90–180mcg daily) are not optional additions to vitamin D supplementation. They are prerequisites for conversion, VDR function, and appropriate calcium direction.

The dose needed to reach functional sufficiency in Scotland is higher than population guidance implies. For someone with a baseline of 40–50 nmol/L in October, targeting 80–100 nmol/L, a daily dose of 2,000–4,000 IU D3 is a clinically reasonable starting point — higher than the NHS recommendation of 400 IU. The GrassrootsHealth D*calculator provides a more individualised estimate based on actual baseline and target.

The body was not designed to receive vitamin D as an isolated high-dose capsule. Skin synthesis produces vitamin D gradually, alongside warmth, nitric oxide production, and other photochemical events. The supplement is a seasonal corrective for a design problem created by the mismatch between our latitude and our modern lifestyle — not a permanent replacement for a system that was never intended to be supplemented. Chronic very high-dose supplementation (10,000 IU+ daily indefinitely) lacks the evidence base to justify it as a population-level recommendation, and creates cofactor imbalance risks that are rarely discussed alongside the advocacy for high targets.

Retest at 12–16 weeks. Vitamin D responds relatively slowly to supplementation. Testing too early produces misleading results. Testing at 12–16 weeks allows you to assess whether the dose has achieved the target and adjust accordingly. This is not optional — it converts supplementation from guesswork into a clinical intervention with a measurable outcome.

Individual variation is the rule, not the exception. The same dose produces different blood levels in different people based on body weight, gut absorption, baseline level, VDR genetics, and cofactor status. What works for one person at your latitude is not necessarily what will work for you. The data — not the average — should guide the decision.

"We were not designed to consume high-dose isolated nutrients in order to survive. We were designed to live in environments that provided what we needed — and to eat the foods that those environments offered. Supplementation is the corrective for the gap between that design and the life we're actually living. Not a replacement for understanding why the gap exists."

The food-first position — what's actually available

Dietary vitamin D from food alone cannot compensate for the Scottish UVB deficit in winter. That is the honest answer. 100g of wild Atlantic salmon provides approximately 400–700 IU. Mackerel, herring, and sardines are in a similar range. A teaspoon of cod liver oil provides 400–1,000 IU depending on the product. Egg yolks from pasture-raised hens contribute 40–100 IU each. Full-fat dairy contributes modest amounts. A diet that genuinely prioritises these sources daily will provide 1,000–2,000 IU from food — meaningful but insufficient on its own to reach functional optimal levels for someone starting low at a Scottish latitude in October.

This is not an argument against food-first. It is an argument for understanding what food-first can and cannot achieve at this latitude in this season, so that the supplementation discussion is grounded in realistic expectations rather than either dismissal or excessive reliance on capsules.

Eat the fatty fish. Reconsider the cod liver oil your grandparents used. Get outside between 11am and 3pm in summer without sunscreen on bare arms for 20–30 minutes — and don't shower for a few hours after. Test your baseline. Supplement intelligently to functional sufficiency. Retest. Adjust. That is the protocol. It is not complicated. It is just not what the average vitamin D conversation sounds like.

Know your actual vitamin D status — not population guidance

25-OH-D is part of the Randox blood chemistry panel in the TDG Five-Test Programme, read alongside calcium, magnesium, PTH, inflammatory markers, and the full metabolic picture. The number in context — not the number alone — is where the clinical decision lives.

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