Each edition of this series takes one complaint people put down to age, and asks the same questions every time: what goes wrong, what’s sold to you, what the trials show, what’s worth testing, and when not to wait. Everything is graded the same way, a supplement to the same standard as a drug or an operation. And there’s one standing section: what’s sold to you vs what works and can’t be sold.
The grades: Strong means large or repeated randomised trials agree. Moderate or Mixed means trials help but are smaller, less certain or disagree. Observational or Mechanistic means measured in people as they live, or in the lab, not tested as a treatment. No benefit means it was tested properly and didn’t work. Guideline means what NICE recommends.
1. Is it just age?
Partly. Knee osteoarthritis is more common as we get older, and NICE uses “45 or over” as one of its diagnostic signs. But age is a real variable with a smaller share than people assume. The useful question is which part of your knee problem is age and which part is something you can change: strength, weight, how much you move, and how you load the joint.
Two things worth knowing before you accept “it’s your age”:
- What a scan shows and what you feel often don’t match. Across population studies, between 15% and 76% of people with knee pain had osteoarthritis on X-ray, and between 15% and 81% of people with osteoarthritis on X-ray had pain (Bedson 2008). In ordinary people aged 50 to 90, an MRI found meniscal tears in 19% of women in their fifties and 56% of men over 70, and 61% of those with tears had had no recent pain, aching or stiffness (Englund 2008). A finding on a scan doesn’t by itself explain your pain. (If you’ve been told a meniscus tear “can’t heal”, read They Told Him It Couldn’t Heal.)
- Muscle responds at any age. Ten frail nursing-home residents, average age 90, did eight weeks of heavy strength training. Their strength went up by an average of 174%, and walking speed by 48% (Fiatarone 1990). Tiny, uncontrolled A demonstration, not proof. Tissue tolerance and how fast you can progress do change with age. Whether muscle can still respond doesn’t.
And one on mindset, graded honestly: people aged 50 and over with more positive views of their own ageing lived 7.5 years longer over 23 years of follow-up, after adjusting for age, sex, income, loneliness and health (Levy 2002). Observational It can’t tell us whether the outlook caused the longer life or reflected something else. But “I can’t at my age” is worth questioning before you accept it.
2. What NICE actually recommends
The UK guideline for osteoarthritis (NICE NG226, 2022) is clear and, for many people, surprising:
- It’s diagnosed clinically, usually without a scan, if you’re 45 or over, have activity-related joint pain, and have no morning stiffness or stiffness lasting no more than 30 minutes. Imaging isn’t routinely needed unless something is unusual.
- The core treatments are therapeutic exercise and, if relevant, weight loss. NICE says to “offer therapeutic exercise tailored to their needs” to everyone with osteoarthritis.
- It warns you honestly: pain may increase when you start exercising, and long-term adherence is what brings the benefit.
- On weight: “any amount of weight loss is likely to be beneficial”, and losing 10% of body weight is likely to be better than 5%.
- First medicine for the knee: a topical anti-inflammatory gel (a topical NSAID).
3. What’s sold to you vs what works and can’t be sold
What’s sold: joint supplements, electrical muscle stimulators, braces and supports, injections, and keyhole surgery. Some of these are advertised heavily, sometimes by famous faces.
What works best: getting stronger, moving more, and carrying less weight. Nobody can patent a squat, so nobody advertises it.
That’s not a dig at everything in a bottle or a box. Below is how each one did in trials, graded the same way.
Things you do
| What | What happened | Source | Grade |
|---|---|---|---|
| Therapeutic exercise | Pain about 12 points lower on a 100-point scale, function about 10 points better (2015 review, 44 trials). The 2024 update (139 trials, 12,468 people) found similar or slightly smaller gains (pain 9–13 points, function 11–13), “of uncertain clinical importance” against a 12-point threshold, and most trials couldn’t blind people to what they were doing | Cochrane: Fransen 2015; Lawford 2024 | Moderate Effect modest. The best we have, not a miracle |
| Type and amount of exercise | No type of exercise beat another, and more sessions didn’t mean more benefit | Lawford 2024; de Wit 2025 (14 trials) | Low |
| Weight loss plus exercise (overweight adults 55+) | Over 18 months, diet plus exercise (about 11% weight loss) gave less pain and better function than exercise alone; diet reduced the compressive load through the knee | IDEA trial, Messier 2013 | Strong One large RCT, consistent with NICE |
| Running | Hip or knee osteoarthritis in 3.5% of recreational runners, 10.2% of non-runners and 13.3% of elite runners | Alentorn-Geli 2017 (17 studies, about 115,000 people) | Observational Running for fun doesn’t appear to wear knees out; people who run may differ in other ways |
The honest reading of the exercise evidence: it helps most people a moderate amount, it’s safe, and its benefits don’t stop at your knees (exercise also lowers blood pressure; see the heart markers post). But the 2024 Cochrane update is right that the average benefit is smaller than people expect. That’s a reason to do it properly and stick with it, not a reason to buy something instead.
Things that are sold
| What | What happened | Source | Grade |
|---|---|---|---|
| Glucosamine and chondroitin | In 1,583 people, neither alone nor together beat placebo for pain; the anti-inflammatory drug celecoxib did. A network meta-analysis of 10 large trials found no clinically relevant effect on pain or joint space, and industry-funded trials showed bigger effects than independent ones. NICE: “Do not offer glucosamine” | GAIT, Clegg 2006; Wandel 2010; NICE 1.4.6 | No benefit Strong evidence |
| Turmeric or curcumin extracts | Pain lower than placebo (SMD −0.82) in 16 trials of up to 16 weeks, similar to anti-inflammatory drugs, with fewer side effects. But trials were short, very inconsistent with each other and at moderate risk of bias, and the benefit was smaller in people with a higher BMI | Wang 2021 | Mixed Promising, low certainty. NICE doesn’t cover it |
| Vitamin D (knee osteoarthritis and low vitamin D) | Two years of supplements raised blood levels but didn’t change knee pain or cartilage loss compared with placebo | Jin 2016, JAMA (413 people) | No benefit For the knee |
| Electrical muscle stimulation (EMS/NMES) | On its own: no consistent improvement in pain, disability, strength or walking distance (8 trials). Added to exercise: possibly a little less pain at 8–12 weeks, very low certainty. NICE: do not offer NMES, TENS, ultrasound, laser or other electrotherapy for osteoarthritis, citing “insufficient evidence of benefit” | Samarkandi 2026; da Silva 2026; NICE 1.3.9 | No benefit On its own; very low certainty as an add-on |
| Braces, insoles, supports | NICE: not routinely; only for instability, or when exercise isn’t possible without one | NICE 1.3.11 | Guideline |
Fair to the devices: electrical stimulation can help someone who can’t yet contract their thigh muscle properly, for example after surgery, as part of supervised rehab. That’s not the same as a gadget doing your exercise for you.
Conventional treatments, same standard
| What | What happened | Source | Grade |
|---|---|---|---|
| Keyhole surgery to “clean out” the knee (washout or debridement) | Against fake surgery (incisions only), no less pain or better function at any point over 2 years. Added to physio and medicines, no extra benefit at 2 years. NICE: “Do not offer arthroscopic lavage or debridement” | Moseley 2002 (sham-controlled); Kirkley 2008; NICE 1.7.1 | No benefit Strong evidence |
| Steroid injections | NICE: consider when other medicines haven’t worked, but relief lasts only 2–10 weeks. Repeated every 3 months for 2 years: more cartilage loss than saline and no difference in pain | NICE 1.4.10; McAlindon 2017, JAMA | Short-term only Repeated use not supported |
| Hyaluronic acid (“gel”) injections | Pain about 2 mm lower on a 100 mm scale than placebo, below what people notice, with more serious adverse events (RR 1.49). NICE: do not offer | Pereira 2022, BMJ; NICE 1.4.9 | No benefit And some harm |
| Platelet-rich plasma (PRP) | No difference from saline in pain or cartilage at 12 months | RESTORE, Bennell 2021, JAMA | No benefit |
| Strong opioids | NICE: do not offer for osteoarthritis | NICE 1.4.6 | Guideline |
| Knee replacement | NICE: consider referral when symptoms substantially affect quality of life and non-surgical care hasn’t worked or isn’t suitable. Don’t exclude people for age, weight or smoking | NICE 1.6.1–1.6.3 | Guideline |
Notice the pattern. Some of the most expensive conventional options failed their trials too. The standard I use doesn’t care whether something comes from a pharmacy, a clinic or a health-food shop.
Myth: “never let your knees go past your toes”
Plenty of people were taught this, and some are now afraid to squat at all. In a small lab study, seven trained men squatted with and without a barrier stopping their knees travelling forward. Blocking the knees cut the load at the knee a little, but the load at the hip went up roughly tenfold, with more forward lean of the trunk. The authors concluded that good loading “may require the knees to move slightly past the toes” (Fry 2003).
My view: the knee is often the victim, not the culprit
This is my strongest position on knees, and it comes from nearly forty years of watching people move rather than from a trial. I think of the knee as a slave joint. It sits between the ankle and the hip and does what they let it do. In running, jumping, changing direction, and even something as ordinary as a squat, the load is meant to be shared across all three joints bending together: ankle, knee and hip, what coaches call triple flexion. When one link can’t play its part, something else has to make up for it.
The most common missing link I see is the ankle. If it can’t bend forward enough, the knee and the hip take more than their share, and in fast or agility movements the knee takes the worst of it. The other is timing. Moving well is a coordinated skill, with a rhythm to it, and people lose that skill without noticing. When it goes, the joints stop sharing the load, and both how much you can carry and how well you move suffer.

I hear “it’s arthritis” a lot. Sometimes it is. Often, in my experience, it’s overuse, with or without faulty movement. And many times, when we correct the movement skill, people have less pain in the moment and less joint pain after exercise.
4. What’s worth testing
For knee osteoarthritis itself, I wouldn’t sell you a blood test. No blood test diagnoses it, and NICE says a scan usually isn’t needed either.
What is worth checking:
- With your GP: morning stiffness that lasts longer than 30 minutes, swelling in several joints, or a hot swollen joint. These point away from osteoarthritis and need medical tests.
- What you can measure yourself, or with me: how far your knee can travel forward over your toes with the heel down (ankle bend), thigh strength in each leg compared side to side, how long you can hold a single-leg position, how you get up from a chair without your hands, your weight over time. These change with training, and they’re what the exercise trials actually move.
- Your wider health, because the same habits drive both: HbA1c, blood pressure and weight. See the heart markers post.
5. When not to wait
From NHS guidance on knee pain (Midlands Partnership NHS Foundation Trust).
Go to A&E if:
- your knee or leg looks newly deformed or misshapen;
- your knee is locked and won’t move, or you can’t put any weight through your leg;
- you have severe knee pain with redness or heat around the knee and you feel unwell (this can be a joint infection);
- you’ve had a serious fall or injury, especially if you have osteoporosis.
See your GP if:
- you feel unwell, have a fever or unexplained weight loss;
- your knee locks or gives way when you put weight on it;
- the pain has suddenly got much worse despite self-help, or hasn’t improved after a couple of weeks.
Throbbing pain and swelling in one leg, usually in the calf or thigh, can be a blood clot (DVT). The NHS says to ask for an urgent GP appointment or get help from NHS 111, and to call 999 or go to A&E if you also feel short of breath or have chest pain.
6. Where to start
- Get a diagnosis you trust. If it fits the NICE picture, you probably don’t need a scan.
- Look above and below the knee. Check your ankles and hips, and how you squat, step and land, before blaming the knee itself.
- Start strengthening and keep going. NICE warns pain may increase at first; that’s expected, not a sign to stop. Any type of exercise counts; consistency matters more than the programme.
- If you’re carrying extra weight, any loss helps, and 10% helps more than 5%.
- Before buying anything, check it against the tables above.
- Don’t stop or start medicines without your GP or pharmacist.


I’m a personal trainer as well as a nutrition practitioner, so I have an interest in telling you exercise works. I also sell supplements. That’s why both are held to the same standard here, and why the evidence on exercise is reported as modest where it is.
Sources
- NICE NG226. Osteoarthritis in over 16s: diagnosis and management (2022), recommendations 1.1.1–1.1.2, 1.2.2–1.2.3, 1.3.1–1.3.5, 1.3.8–1.3.9, 1.3.11, 1.4.2, 1.4.5–1.4.6, 1.4.9–1.4.10, 1.6.1–1.6.3, 1.7.1. nice.org.uk/guidance/ng226
- Fransen M et al. Exercise for osteoarthritis of the knee. Cochrane 2015. PMID 25569281. doi:10.1002/14651858.CD004376.pub3
- Lawford BJ et al. Exercise for osteoarthritis of the knee. Cochrane 2024. PMID 39625083. doi:10.1002/14651858.CD004376.pub4
- de Wit 2025. Musculoskeletal Care. PMID 40320557. doi:10.1002/msc.70110
- Messier SP et al. (IDEA). JAMA 2013. PMID 24065013. doi:10.1001/jama.2013.277669
- Alentorn-Geli E et al. J Orthop Sports Phys Ther 2017. PMID 28504066. doi:10.2519/jospt.2017.7137
- Bedson J, Croft PR. BMC Musculoskelet Disord 2008. PMID 18764949. doi:10.1186/1471-2474-9-116
- Englund M et al. Incidental meniscal findings on knee MRI in middle-aged and elderly persons. NEJM 2008. PMID 18784100. doi:10.1056/NEJMoa0800777
- Fiatarone MA et al. High-intensity strength training in nonagenarians. JAMA 1990. PMID 2342214. PubMed
- Levy BR et al. Longevity increased by positive self-perceptions of aging. J Pers Soc Psychol 2002. PMID 12150226. doi:10.1037//0022-3514.83.2.261
- Clegg DO et al. (GAIT). NEJM 2006. PMID 16495392. doi:10.1056/NEJMoa052771
- Wandel S et al. BMJ 2010. PMID 20847017. doi:10.1136/bmj.c4675
- Wang Z et al. Curr Rheumatol Rep 2021. PMID 33511486. doi:10.1007/s11926-020-00975-8
- Jin X et al. JAMA 2016. PMID 26954409. doi:10.1001/jama.2016.1961
- Samarkandi 2026. Orthop Rev (Pavia). PMID 42688924. doi:10.52965/001c.168252
- da Silva 2026. Disabil Rehabil. PMID 41742784. doi:10.1080/09638288.2026.2633271
- Moseley JB et al. NEJM 2002. PMID 12110735. doi:10.1056/NEJMoa013259
- Kirkley A et al. NEJM 2008. PMID 18784099. doi:10.1056/NEJMoa0708333
- McAlindon TE et al. JAMA 2017. PMID 28510679. doi:10.1001/jama.2017.5283
- Pereira TV et al. BMJ 2022. PMID 36333100. doi:10.1136/bmj-2022-069722
- Bennell KL et al. (RESTORE). JAMA 2021. PMID 34812863. doi:10.1001/jama.2021.19415
- Fry AC et al. Effect of knee position on hip and knee torques during the barbell squat. J Strength Cond Res 2003. PMID 14636100. PubMed
- Macrum E et al. Effect of limiting ankle-dorsiflexion range of motion on lower extremity kinematics and muscle-activation patterns during a squat. J Sport Rehabil 2012. PMID 22100617. doi:10.1123/jsr.21.2.144
- Malliaras P, Cook JL, Kent P. Reduced ankle dorsiflexion range may increase the risk of patellar tendon injury among volleyball players. J Sci Med Sport 2006. PMID 16672192. doi:10.1016/j.jsams.2006.03.015
- Willy RW, Scholz JP, Davis IS. Mirror gait retraining for the treatment of patellofemoral pain in female runners. Clin Biomech 2012. PMID 22917625. doi:10.1016/j.clinbiomech.2012.07.011
- NHS. Deep vein thrombosis (DVT). nhs.uk, read 8 October 2026.
- Midlands Partnership NHS Foundation Trust. MSK self-help: knee. mpft.nhs.uk, read 7 October 2026.