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“I’m Not Getting Any Younger” · Edition 1
Musculoskeletal · Evidence graded

“I’m Not Getting Any Younger”: Knees

Sore knees get blamed on age more than almost anything else. Age plays a part, but a smaller one than you’ve been told. Here’s what the trials say works, what’s sold to you instead, and the treatments, conventional and natural, that didn’t hold up.

Stephen Duncan FDN-P MSc · Detective Health · October 2026 · 11 min read

Each edition of this series takes one complaint people put down to age, and asks the same questions every time: what goes wrong, what’s sold to you, what the trials show, what’s worth testing, and when not to wait. Everything is graded the same way, a supplement to the same standard as a drug or an operation. And there’s one standing section: what’s sold to you vs what works and can’t be sold.

The grades: Strong means large or repeated randomised trials agree. Moderate or Mixed means trials help but are smaller, less certain or disagree. Observational or Mechanistic means measured in people as they live, or in the lab, not tested as a treatment. No benefit means it was tested properly and didn’t work. Guideline means what NICE recommends.

1. Is it just age?

Partly. Knee osteoarthritis is more common as we get older, and NICE uses “45 or over” as one of its diagnostic signs. But age is a real variable with a smaller share than people assume. The useful question is which part of your knee problem is age and which part is something you can change: strength, weight, how much you move, and how you load the joint.

Two things worth knowing before you accept “it’s your age”:

And one on mindset, graded honestly: people aged 50 and over with more positive views of their own ageing lived 7.5 years longer over 23 years of follow-up, after adjusting for age, sex, income, loneliness and health (Levy 2002). Observational It can’t tell us whether the outlook caused the longer life or reflected something else. But “I can’t at my age” is worth questioning before you accept it.

2. What NICE actually recommends

The UK guideline for osteoarthritis (NICE NG226, 2022) is clear and, for many people, surprising:

3. What’s sold to you vs what works and can’t be sold

What’s sold: joint supplements, electrical muscle stimulators, braces and supports, injections, and keyhole surgery. Some of these are advertised heavily, sometimes by famous faces.

What works best: getting stronger, moving more, and carrying less weight. Nobody can patent a squat, so nobody advertises it.

That’s not a dig at everything in a bottle or a box. Below is how each one did in trials, graded the same way.

Things you do

WhatWhat happenedSourceGrade
Therapeutic exercisePain about 12 points lower on a 100-point scale, function about 10 points better (2015 review, 44 trials). The 2024 update (139 trials, 12,468 people) found similar or slightly smaller gains (pain 9–13 points, function 11–13), “of uncertain clinical importance” against a 12-point threshold, and most trials couldn’t blind people to what they were doingCochrane: Fransen 2015; Lawford 2024Moderate Effect modest. The best we have, not a miracle
Type and amount of exerciseNo type of exercise beat another, and more sessions didn’t mean more benefitLawford 2024; de Wit 2025 (14 trials)Low
Weight loss plus exercise (overweight adults 55+)Over 18 months, diet plus exercise (about 11% weight loss) gave less pain and better function than exercise alone; diet reduced the compressive load through the kneeIDEA trial, Messier 2013Strong One large RCT, consistent with NICE
RunningHip or knee osteoarthritis in 3.5% of recreational runners, 10.2% of non-runners and 13.3% of elite runnersAlentorn-Geli 2017 (17 studies, about 115,000 people)Observational Running for fun doesn’t appear to wear knees out; people who run may differ in other ways

The honest reading of the exercise evidence: it helps most people a moderate amount, it’s safe, and its benefits don’t stop at your knees (exercise also lowers blood pressure; see the heart markers post). But the 2024 Cochrane update is right that the average benefit is smaller than people expect. That’s a reason to do it properly and stick with it, not a reason to buy something instead.

Things that are sold

WhatWhat happenedSourceGrade
Glucosamine and chondroitinIn 1,583 people, neither alone nor together beat placebo for pain; the anti-inflammatory drug celecoxib did. A network meta-analysis of 10 large trials found no clinically relevant effect on pain or joint space, and industry-funded trials showed bigger effects than independent ones. NICE: “Do not offer glucosamine”GAIT, Clegg 2006; Wandel 2010; NICE 1.4.6No benefit Strong evidence
Turmeric or curcumin extractsPain lower than placebo (SMD −0.82) in 16 trials of up to 16 weeks, similar to anti-inflammatory drugs, with fewer side effects. But trials were short, very inconsistent with each other and at moderate risk of bias, and the benefit was smaller in people with a higher BMIWang 2021Mixed Promising, low certainty. NICE doesn’t cover it
Vitamin D (knee osteoarthritis and low vitamin D)Two years of supplements raised blood levels but didn’t change knee pain or cartilage loss compared with placeboJin 2016, JAMA (413 people)No benefit For the knee
Electrical muscle stimulation (EMS/NMES)On its own: no consistent improvement in pain, disability, strength or walking distance (8 trials). Added to exercise: possibly a little less pain at 8–12 weeks, very low certainty. NICE: do not offer NMES, TENS, ultrasound, laser or other electrotherapy for osteoarthritis, citing “insufficient evidence of benefit”Samarkandi 2026; da Silva 2026; NICE 1.3.9No benefit On its own; very low certainty as an add-on
Braces, insoles, supportsNICE: not routinely; only for instability, or when exercise isn’t possible without oneNICE 1.3.11Guideline

Fair to the devices: electrical stimulation can help someone who can’t yet contract their thigh muscle properly, for example after surgery, as part of supervised rehab. That’s not the same as a gadget doing your exercise for you.

Conventional treatments, same standard

WhatWhat happenedSourceGrade
Keyhole surgery to “clean out” the knee (washout or debridement)Against fake surgery (incisions only), no less pain or better function at any point over 2 years. Added to physio and medicines, no extra benefit at 2 years. NICE: “Do not offer arthroscopic lavage or debridement”Moseley 2002 (sham-controlled); Kirkley 2008; NICE 1.7.1No benefit Strong evidence
Steroid injectionsNICE: consider when other medicines haven’t worked, but relief lasts only 2–10 weeks. Repeated every 3 months for 2 years: more cartilage loss than saline and no difference in painNICE 1.4.10; McAlindon 2017, JAMAShort-term only Repeated use not supported
Hyaluronic acid (“gel”) injectionsPain about 2 mm lower on a 100 mm scale than placebo, below what people notice, with more serious adverse events (RR 1.49). NICE: do not offerPereira 2022, BMJ; NICE 1.4.9No benefit And some harm
Platelet-rich plasma (PRP)No difference from saline in pain or cartilage at 12 monthsRESTORE, Bennell 2021, JAMANo benefit
Strong opioidsNICE: do not offer for osteoarthritisNICE 1.4.6Guideline
Knee replacementNICE: consider referral when symptoms substantially affect quality of life and non-surgical care hasn’t worked or isn’t suitable. Don’t exclude people for age, weight or smokingNICE 1.6.1–1.6.3Guideline

Notice the pattern. Some of the most expensive conventional options failed their trials too. The standard I use doesn’t care whether something comes from a pharmacy, a clinic or a health-food shop.

Myth: “never let your knees go past your toes”

Plenty of people were taught this, and some are now afraid to squat at all. In a small lab study, seven trained men squatted with and without a barrier stopping their knees travelling forward. Blocking the knees cut the load at the knee a little, but the load at the hip went up roughly tenfold, with more forward lean of the trunk. The authors concluded that good loading “may require the knees to move slightly past the toes” (Fry 2003).

⚖
Grade: Mechanistic. One small study of young lifters. The point isn’t that anything goes. It’s that a joint is part of a chain, and protecting one link by overloading another isn’t protection. How far your knees travel should depend on your ankles, your hips and what you can control, not on a rule.

My view: the knee is often the victim, not the culprit

This is my strongest position on knees, and it comes from nearly forty years of watching people move rather than from a trial. I think of the knee as a slave joint. It sits between the ankle and the hip and does what they let it do. In running, jumping, changing direction, and even something as ordinary as a squat, the load is meant to be shared across all three joints bending together: ankle, knee and hip, what coaches call triple flexion. When one link can’t play its part, something else has to make up for it.

The most common missing link I see is the ankle. If it can’t bend forward enough, the knee and the hip take more than their share, and in fast or agility movements the knee takes the worst of it. The other is timing. Moving well is a coordinated skill, with a rhythm to it, and people lose that skill without noticing. When it goes, the joints stop sharing the load, and both how much you can carry and how well you move suffer.

Stephen in a bodyweight squat, front view, arms by his sides, knees over his feet and heels on the ground
Bodyweight squat. Knees tracking over the second toe, heels down.

I hear “it’s arthritis” a lot. Sometimes it is. Often, in my experience, it’s overuse, with or without faulty movement. And many times, when we correct the movement skill, people have less pain in the moment and less joint pain after exercise.

⚖
Grade: my observation. First-hand and anecdotal; I haven’t tested it in a trial. Parts of it have support: restricting ankle bend in a squat (30 healthy adults) reduced knee bend and pushed the knees inward (Macrum 2012, lab study); in 113 volleyball players, limited ankle bend was the only measured factor linked with patellar tendon pain (Malliaras 2006, one point in time); and in 10 female runners with kneecap pain, eight sessions of mirror feedback on how they ran changed their hip mechanics and improved pain and function for three months (Willy 2012, small, no control group). None of those studies was in knee osteoarthritis.

4. What’s worth testing

For knee osteoarthritis itself, I wouldn’t sell you a blood test. No blood test diagnoses it, and NICE says a scan usually isn’t needed either.

What is worth checking:

5. When not to wait

From NHS guidance on knee pain (Midlands Partnership NHS Foundation Trust).

Go to A&E if:

See your GP if:

Throbbing pain and swelling in one leg, usually in the calf or thigh, can be a blood clot (DVT). The NHS says to ask for an urgent GP appointment or get help from NHS 111, and to call 999 or go to A&E if you also feel short of breath or have chest pain.

6. Where to start

  1. Get a diagnosis you trust. If it fits the NICE picture, you probably don’t need a scan.
  2. Look above and below the knee. Check your ankles and hips, and how you squat, step and land, before blaming the knee itself.
  3. Start strengthening and keep going. NICE warns pain may increase at first; that’s expected, not a sign to stop. Any type of exercise counts; consistency matters more than the programme.
  4. If you’re carrying extra weight, any loss helps, and 10% helps more than 5%.
  5. Before buying anything, check it against the tables above.
  6. Don’t stop or start medicines without your GP or pharmacist.
Stephen at the top of a split squat, side view, one foot forward, one arm raisedStephen at the bottom of a split squat, side view, back knee just short of the ground
Split squat, top and bottom. One way to start strengthening: the front knee stays over the second toe all the way down, and the back knee stops just short of the floor.

I’m a personal trainer as well as a nutrition practitioner, so I have an interest in telling you exercise works. I also sell supplements. That’s why both are held to the same standard here, and why the evidence on exercise is reported as modest where it is.

Sources

  1. NICE NG226. Osteoarthritis in over 16s: diagnosis and management (2022), recommendations 1.1.1–1.1.2, 1.2.2–1.2.3, 1.3.1–1.3.5, 1.3.8–1.3.9, 1.3.11, 1.4.2, 1.4.5–1.4.6, 1.4.9–1.4.10, 1.6.1–1.6.3, 1.7.1. nice.org.uk/guidance/ng226
  2. Fransen M et al. Exercise for osteoarthritis of the knee. Cochrane 2015. PMID 25569281. doi:10.1002/14651858.CD004376.pub3
  3. Lawford BJ et al. Exercise for osteoarthritis of the knee. Cochrane 2024. PMID 39625083. doi:10.1002/14651858.CD004376.pub4
  4. de Wit 2025. Musculoskeletal Care. PMID 40320557. doi:10.1002/msc.70110
  5. Messier SP et al. (IDEA). JAMA 2013. PMID 24065013. doi:10.1001/jama.2013.277669
  6. Alentorn-Geli E et al. J Orthop Sports Phys Ther 2017. PMID 28504066. doi:10.2519/jospt.2017.7137
  7. Bedson J, Croft PR. BMC Musculoskelet Disord 2008. PMID 18764949. doi:10.1186/1471-2474-9-116
  8. Englund M et al. Incidental meniscal findings on knee MRI in middle-aged and elderly persons. NEJM 2008. PMID 18784100. doi:10.1056/NEJMoa0800777
  9. Fiatarone MA et al. High-intensity strength training in nonagenarians. JAMA 1990. PMID 2342214. PubMed
  10. Levy BR et al. Longevity increased by positive self-perceptions of aging. J Pers Soc Psychol 2002. PMID 12150226. doi:10.1037//0022-3514.83.2.261
  11. Clegg DO et al. (GAIT). NEJM 2006. PMID 16495392. doi:10.1056/NEJMoa052771
  12. Wandel S et al. BMJ 2010. PMID 20847017. doi:10.1136/bmj.c4675
  13. Wang Z et al. Curr Rheumatol Rep 2021. PMID 33511486. doi:10.1007/s11926-020-00975-8
  14. Jin X et al. JAMA 2016. PMID 26954409. doi:10.1001/jama.2016.1961
  15. Samarkandi 2026. Orthop Rev (Pavia). PMID 42688924. doi:10.52965/001c.168252
  16. da Silva 2026. Disabil Rehabil. PMID 41742784. doi:10.1080/09638288.2026.2633271
  17. Moseley JB et al. NEJM 2002. PMID 12110735. doi:10.1056/NEJMoa013259
  18. Kirkley A et al. NEJM 2008. PMID 18784099. doi:10.1056/NEJMoa0708333
  19. McAlindon TE et al. JAMA 2017. PMID 28510679. doi:10.1001/jama.2017.5283
  20. Pereira TV et al. BMJ 2022. PMID 36333100. doi:10.1136/bmj-2022-069722
  21. Bennell KL et al. (RESTORE). JAMA 2021. PMID 34812863. doi:10.1001/jama.2021.19415
  22. Fry AC et al. Effect of knee position on hip and knee torques during the barbell squat. J Strength Cond Res 2003. PMID 14636100. PubMed
  23. Macrum E et al. Effect of limiting ankle-dorsiflexion range of motion on lower extremity kinematics and muscle-activation patterns during a squat. J Sport Rehabil 2012. PMID 22100617. doi:10.1123/jsr.21.2.144
  24. Malliaras P, Cook JL, Kent P. Reduced ankle dorsiflexion range may increase the risk of patellar tendon injury among volleyball players. J Sci Med Sport 2006. PMID 16672192. doi:10.1016/j.jsams.2006.03.015
  25. Willy RW, Scholz JP, Davis IS. Mirror gait retraining for the treatment of patellofemoral pain in female runners. Clin Biomech 2012. PMID 22917625. doi:10.1016/j.clinbiomech.2012.07.011
  26. NHS. Deep vein thrombosis (DVT). nhs.uk, read 8 October 2026.
  27. Midlands Partnership NHS Foundation Trust. MSK self-help: knee. mpft.nhs.uk, read 7 October 2026.

Your next step

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I’m a personal trainer as well as a nutrition practitioner, and I sell the services above. The article’s grades apply to my advice too.