I'm not going to tell you that ADHD isn't real, that stimulant medication doesn't work, or that you just need to eat more vegetables. ADHD is real. Stimulant medication helps many people significantly. And the system that's asking you to wait 2–3 years for an assessment while your work, relationships, and mental health deteriorate is genuinely failing you.

What I am going to tell you is that the current pathway — assessment, diagnosis, prescription — misses something important. Something measurable. Something that, in my clinical experience, is present in almost every adult who comes to me with significant ADHD-type symptoms, whether diagnosed or not.

The missing piece is this: nobody investigates why the brain isn't working the way it should.

2–3
Year NHS wait average
£1.5k+
Private assessment cost
0
Functional tests typically ordered

The question that almost never gets asked

The current ADHD assessment pathway is built around behavioural observation. You complete questionnaires. A clinician interviews you about your symptoms across multiple life domains. Your history is reviewed. A diagnostic decision is made based on whether your symptom pattern matches the DSM criteria. If it does, you receive a diagnosis. If the diagnosis is ADHD, you receive a prescription for stimulant medication.

That's the pathway. At no point in that pathway does anyone ask: why is your dopamine system underperforming? What in your biochemistry is producing this symptom pattern? Is there something measurable and addressable driving the neurotransmitter deficits that stimulant medication is compensating for?

This matters because stimulant medication — methylphenidate, lisdexamfetamine, atomoxetine — works by increasing dopamine and norepinephrine availability in the prefrontal cortex. It addresses the downstream deficit. It doesn't address why the deficit exists. For many people that's sufficient. For a significant proportion, medication provides partial relief, loses effectiveness over time, or creates problems that complicate the picture. When that happens, the biochemical investigation becomes essential.

The four biochemical root cause clusters

Through clinical practice and five-test functional investigation, I've identified four consistent biochemical patterns that underlie or contribute to ADHD-type presentations. These aren't alternative diagnoses — they're measurable physiological states that can coexist with a genuine ADHD diagnosis and compound it significantly.

Cluster 01
Neurotransmitter System Deficit
The Organic Acids Test directly measures neurotransmitter metabolites: HVA (homovanillic acid — dopamine turnover), VMA (norepinephrine), and 5-HIAA (serotonin). These are not inferred signals from questionnaire responses. They are direct biochemical evidence of how your neurotransmitter systems are functioning. When HVA is low, dopamine production is deficient — not theoretically, but measurably. The kynurenine pathway markers (quinolinic and kynurenic acid) show whether inflammation is diverting tryptophan away from serotonin production. This is what stimulant medication targets — but without understanding why these systems are depleted, medication treats the deficit without addressing its source.
Investigated by: Organic Acids Test (OAT) · DUTCH Plus
Cluster 02
Gut–Brain Axis Disruption
Ninety percent of serotonin is produced in the gut, not the brain. When the gut microbiome is dysbiotic, the bacterial population responsible for synthesising aromatic amino acids — the precursors for dopamine and serotonin — cannot do its job. The result is a neurotransmitter production deficit with a gut origin. Additionally, when gut barrier integrity is compromised (measurable via zonulin on GI-MAP), incompletely digested casein becomes casomorphin and gluten becomes gliadorphin — both are opioid peptides that can cross the blood-brain barrier and bind opioid receptors. This mechanism may explain why some autism spectrum and ADHD presentations improve meaningfully when gluten and dairy are removed. Glyphosate specifically disrupts the bacterial shikimate pathway responsible for neurotransmitter precursor synthesis — relevant for clients with significant dietary exposure.
Investigated by: GI-MAP Stool Analysis · Food Sensitivity Panel (IgG)
Cluster 03
Methylation & Genetic Expression
MTHFR gene variants — which impair the conversion of dietary folate to its active, usable form — are significantly overrepresented in neurodivergent populations. Methylation is the upstream process for all monoamine neurotransmitter synthesis. When methylation is impaired, dopamine and serotonin production is compromised regardless of how many precursors are available. B12, folate, and homocysteine (a direct methylation marker) on blood chemistry, combined with DUTCH methylation indicators, give a comprehensive upstream picture. Zinc-copper dysregulation — consistently found in autism spectrum presentations — affects dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine.
Investigated by: Blood Chemistry (B12, folate, homocysteine, zinc:copper) · DUTCH Plus
Cluster 04
Metabolic Dysregulation
The prefrontal cortex — the brain region responsible for attention, working memory, impulse control, and executive function — is exquisitely sensitive to blood glucose stability. A fasting glucose of 5.8 mmol/L looks normal on every standard panel. In functional medicine it can signal early insulin resistance already impairing prefrontal cortex function. Blood glucose instability drives cortisol release, which disrupts the dopamine system further. Ferritin below 30 — extremely common, routinely missed — independently impairs dopamine transporter function: the exact molecular mechanism that stimulant medication acts on. These are correctable deficits. They are almost never investigated in standard ADHD care.
Investigated by: Blood Chemistry (fasting glucose, insulin, ferritin, HOMA-IR)

Why the waiting period is actually the right time

If you're on a 2-year NHS waiting list, or you've just been assessed privately and have a diagnosis but medication that isn't working as well as you'd like, you have two years in which you can either wait passively or investigate actively. The biochemical investigation doesn't require an ADHD diagnosis to be clinically meaningful. The findings — low ferritin, poor methylation, gut dysbiosis, blood glucose instability — are relevant regardless of diagnostic status, and the interventions produce real changes in how the brain functions.

I've seen clients whose ADHD symptoms improved meaningfully within 8–12 weeks of addressing ferritin deficiency, blood glucose stabilisation, and gut restoration — before they'd reached the top of any waiting list. That's not a cure for ADHD. But it's the difference between a brain trying to function on depleted resources and a brain with the biochemical foundation it needs to use whatever tools — medication, coaching, strategies — are brought to bear.

A client in her mid-thirties came to me while on an 18-month NHS waiting list. She'd been managing significant attentional and executive function difficulties her whole adult life — jobs lost, relationships strained, an exhausting sense of being fundamentally broken in some way she couldn't name. Standard bloods: normal. GP's response: stress management and therapy.

Testing revealed ferritin of 11 (impaired dopamine transport), fasting insulin consistent with early insulin resistance affecting prefrontal cortex function, significant gut dysbiosis with low secretory IgA, and on OAT, substantially low HVA — direct evidence of impaired dopamine production. We addressed each in sequence. Within three months she described her mind as "quieter than it's been in years." She subsequently received her ADHD diagnosis and started medication, which she found significantly more effective on the corrected biochemical foundation than she expected to based on others' experiences.

What functional medicine can and cannot do

To be direct: functional medicine doesn't diagnose ADHD. I'm not an ADHD assessor and the TDG programme isn't a substitute for a proper diagnostic assessment. What it does is investigate the biochemistry that may be driving, compounding, or in some cases mimicking ADHD symptoms — and address whatever measurable deficits are found.

Some of my clients find that addressing these deficits resolves symptoms sufficiently that they choose not to pursue diagnosis or medication. Others find that it makes their diagnosis, when it arrives, easier to work with — because they're not fighting both ADHD and a depleted biochemical foundation simultaneously. Neither outcome can be predicted in advance. What can be established in advance is whether the biochemical patterns are present — and that takes five tests and about four weeks.

A free starting point

The Neurodivergent Biochemical Screen is a free 18-question tool that identifies which of the four biochemical clusters is most likely active in your presentation. It doesn't diagnose anything. It provides a clinical orientation — a starting point that identifies where investigation is most likely to be productive, and which of the five TDG tests are most relevant to your specific pattern.

Find your biochemical root cause cluster
The free Neurodivergent Biochemical Screen takes 3 minutes. It identifies your dominant root cause cluster — Neurotransmitter, Gut-Brain Axis, Methylation, or Metabolic — and explains which tests are most relevant to your presentation. No email required. If the screen suggests a clinical investigation, the discovery consultation is the next step.
Take the Free Screen → Book a Consultation — £145
Stephen Duncan
FDN-P · MSc · Edinburgh · 37 Years Clinical Experience
Stephen Duncan is a Functional Diagnostic Nutrition Practitioner and founder of Detective Health. His neurodivergent methodology investigates the four biochemical root cause clusters — neurotransmitter, gut-brain axis, methylation, and metabolic — through five-test functional laboratory analysis. He does not diagnose ADHD or any other condition. © 2026 Stephen Duncan Nutrition. All rights reserved. The TDG Clinical Framework and Neurodivergent Biochemical Cluster system are proprietary intellectual property of Stephen Duncan Nutrition.