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Food Sensitivity · The Most Underdiagnosed Category

The 30 Spices We Test — And Why Nobody Tests Them

Standard IgG panels test 5–10 spices. The HealthBeings panel tests 30 — individually. Turmeric, coriander, cumin, fenugreek, cardamom, ginger: the anti-inflammatory foods of the wellness world are consumed multiple times daily, never suspected, and almost never tested. Spice reactivity may be the most under-diagnosed food sensitivity pattern in clinical practice.

STEPHEN DUNCAN FDN-P BSC HONS MSC · DETECTIVE HEALTH · JULY 2026

If you asked most people to list the foods most likely to be causing their IgG food reactivity, spices would not feature prominently. They are consumed in small quantities. They are widely considered anti-inflammatory. Turmeric is in everything the health-conscious world eats. Ginger and cinnamon are in every wellness protocol. Nobody is eliminating cumin.

Which is exactly why spice reactivity is the most under-diagnosed food sensitivity pattern in clinical practice. The foods most likely to escape clinical suspicion are the ones consumed multiple times daily without being categorised as food. Spices are seasoning, not food. They are not on the mental list of things that could be causing symptoms. And because standard IgG panels test 5–10 spices at most, they have remained safely outside the testing framework entirely — until now.

Thirty Spices Tested Individually

The HealthBeings IgG food panel (286 foods) tests 30 spices as individual antigens. This includes all five pepper colours (black, white, green, red, yellow) as a combined marker, plus: anise, basil, bay leaf, caraway, cardamom, cayenne pepper, chili (red), cinnamon, clove, coriander, cumin, curry powder, dill, fenugreek, ginger, juniper berry, lemongrass, mint, mustard, nutmeg, oregano, paprika, parsley, rosemary, sage, tarragon, thyme, turmeric, and vanilla.

Most of these are present in the kitchens of people who consider themselves health-conscious. Many are consumed multiple times daily. Several — turmeric, ginger, cinnamon, coriander, cumin — have been elevated to superfood status and appear in daily supplement form as well as in food.

Why spice reactivity is clinically different from other food reactions

Spices are dose-concentrated. A single curry contains more cumin, coriander, and fenugreek by weight than a typical serving of most other foods. Spice extracts and supplements concentrate this further — a turmeric capsule delivering 500mg of curcumin represents a substantially higher antigen exposure than sprinkling turmeric on food.

Spices are also cross-reactive. The Apiaceae family (carrot family) includes coriander, cumin, dill, parsley, fennel, caraway, and anise — a client reacting to one may react to several through cross-reactive proteins. The same pattern applies within the Lamiaceae (mint family): basil, oregano, sage, rosemary, thyme, mint. Understanding botanical families helps predict cross-reactivity patterns.

Fenugreek, Coriander, and South Asian Diet Patterns

Fenugreek and coriander deserve specific mention because their clinical significance in UK practice extends beyond the general spice reactivity picture. Both are staple spices in South Asian cooking and are present in virtually every curry, dal, and spiced dish in that dietary tradition. Both have also been elevated to health supplement status — fenugreek is sold as a capsule for blood sugar management and breastfeeding support; coriander seed is promoted for digestive health.

A client of South Asian heritage who eats a traditional diet is consuming fenugreek and coriander multiple times daily at every meal. If they react at Class 3 to either on the IgG panel, they are experiencing significant immune activation with every meal in a pattern that would be entirely invisible without testing. The foods are embedded in cultural and family food practices in a way that makes them psychologically difficult to eliminate even when the reactivity is identified — requiring a careful, culturally sensitive approach to the elimination protocol. This is my practice rule. The lab’s IgG classes haven’t been tested against outcomes (evidence grade: none).

Turmeric and the Anti-Inflammatory Paradox

Turmeric is the clearest example of the anti-inflammatory paradox in spice reactivity. Curcumin, the active compound in turmeric, has a substantial evidence base for anti-inflammatory properties. Turmeric supplementation at therapeutic doses is a clinically reasonable intervention for inflammatory conditions. And yet: if an individual has developed IgG reactivity to turmeric, their daily turmeric consumption — however well-intentioned — is triggering a daily immune response that generates inflammation.

The anti-inflammatory effect of curcumin operates through one mechanism (NF-kB suppression, COX inhibition). The IgG immune reaction to turmeric operates through a different mechanism (immune complex formation, mast cell activation, cytokine release). These mechanisms can coexist. An individual can be simultaneously receiving anti-inflammatory benefit from curcumin biochemistry while experiencing pro-inflammatory immune activation from IgG reactivity to the same compound. Testing determines which effect is dominating.

Mustard — The Hidden Allergen

Mustard is a declared allergen under UK and EU food labelling law (one of the 14 major allergens). It is required to be labelled in packaged foods. It is not required to be declared in many catering contexts. And it is present, in varying forms, in an extraordinary range of processed foods, sauces, dressings, and condiments where its presence is not obvious. Mustard IgG reactivity — even at IgG (delayed) rather than IgE (immediate) level — in a client consuming processed foods regularly represents a significant hidden antigen exposure.

The spices in your kitchen are not seasonings. They are repeated daily antigen exposures. If your gut barrier is compromised, your immune system is responding to them. Turmeric being anti-inflammatory does not make it immune to causing immune reactions in you specifically. Test before assuming.
Testing the spice question

The HealthBeings IgG food panel (286 foods) tests 30 spices individually — more than any other commercially available IgG panel in the UK. One proposed explanation for spice reactivity is a strained gut barrier meeting concentrated botanical antigens several times a day. No routine test confirms that in one person; GI-MAP’s zonulin add-on does not measure permeability. The elimination protocol for spice reactivity requires understanding botanical cross-reactive families to avoid inadvertent ongoing exposure through related species. This level of interpretation is what a full clinical assessment provides alongside the test result.

Could a food you think is helping actually be causing harm?

The HealthBeings IgG food panel (286 foods) tests each food individually — with no assumptions about which ones are good for you. Part of the TDG Five-Test Programme.

About the 286-marker panel → Book a free 20-minute call