GUT BARRIER INTEGRITY
HOW INTESTINAL PERMEABILITY DRIVES SYSTEMIC INFLAMMATION
HEALTHY BARRIER
GUT LUMEN
food
bact.
fibre
IgA
TJ
TJ
TJ
TJ
TJ
BLOODSTREAM
✓
✓
✓
Nutrients absorbed · pathogens blocked
✓ Secretory IgA protective
Normal sIgA: 510–2040 mg/g on GI-MAP
COMPROMISED BARRIER
GUT LUMEN
LPS
toxin
pathogen
gluten
candida
✗
✗
✗
✗
ZONULIN ↑
BLOODSTREAM — IMMUNE ALERT
IgG
IL-6↑
TNF↑
Undigested proteins · toxins · pathogens entering
↑ Calprotectin · ↑ Zonulin on GI-MAP
Skin: eczema, acne, psoriasis
Brain: fog, anxiety, mood · Joints: pain
Autoimmune trigger: molecular mimicry
MEASURED BY
GI-MAP
sIgA · Zonulin
Calprotectin
THE 5R GUT RESTORATION PROTOCOL — IN SEQUENCE
REMOVE
STEP 1
Pathogens
Reactive foods
Unnecessary meds
Alcohol · stress
GI-MAP identifies
targets precisely
→
REPLACE
STEP 2
HCl if low
Digestive enzymes
Bile support
Ox bile if needed
Elastase <200 on
GI-MAP = deficient
→
REINOCULATE
STEP 3
Targeted probiotics
Fermented foods
Prebiotic fibre
Akkermansia support
Only after removal —
not into infection
→
REPAIR
STEP 4
L-glutamine
Zinc carnosine
Collagen peptides
Omega-3 EPA/DHA
Heal tight junctions
reduce calprotectin
→
REBALANCE
STEP 5 · ONGOING
Stress management
Sleep quality
Slow eating
Parasympathetic dining
The lifestyle that
created it must change
DETECTIVE HEALTH · STEPHEN DUNCAN MSC FDN-P · GI-MAP TESTING · DETECTIVE-HEALTH.COM